Medical Weight Loss in Naples, FL
A plan built around you.
Medical weight loss in Naples, FL from Optimal Wellness Naples, rated 5.0 on Google from 540+ reviews, with every program physician-supervised by Victor Cruz, MD. Compounded semaglutide or tirzepatide is prescribed only when it's appropriate for you.
- Free consultation
- Physician-supervised
- Price before you commit

GLP-1 programs, prescribed with care.
We're a physician-supervised GLP-1 clinic in downtown Naples. When medication is appropriate, we prescribe compounded semaglutide or tirzepatide, prepared by a licensed Florida compounding pharmacy.
Which one fits, if either, is a clinical decision made with you at your consultation. It isn't chosen from a menu.
Semaglutide
A prescription GLP-1 medication that helps regulate appetite and food intake. It's used for weight loss under medical supervision, and your clinician goes through what to expect and the side effects before you start.
Tirzepatide
A prescription medication that acts on two appetite-related hormone pathways, GLP-1 and GIP. It's used for weight loss under medical supervision, and your clinician goes through what to expect and the side effects before you start.
Lipotropic injections
B vitamins and amino acids often used alongside a weight-loss program. Your clinician explains what they can and can't do, and their side effects, before you start.
What your program includes
Every program is prescribed and supervised by our clinical team.
- A full review of your history, goals and current medications
- A prescription only if it's appropriate for you
- Follow-ups to adjust your plan and manage side effects
- Guidance on food and habits, not just medication
Not right for everyone
GLP-1 medications aren't suitable for everyone. Your clinician checks your history, current medications and anything that would rule them out before anything's prescribed.
Straight answers about what you're taking.
You'll hear the word "compounded" a lot in GLP-1 weight loss. Here's what it means for the medication we prescribe.
FDA-approved
- What it is
- A medication made by its original manufacturer and approved by the FDA for specific uses in eligible patients.
- FDA review
- Reviewed by the FDA for safety and effectiveness in the uses it's approved for.
Not FDA-approved
- What it is
- Prepared for an individual prescription by a licensed Florida compounding pharmacy. This is what we prescribe.
- FDA review
- Compounded medications aren't FDA-approved. The FDA doesn't review them for safety, effectiveness or quality before they're dispensed.
- What we do
- Your clinician tells you what you're prescribed, how it's given and its side effects before you start.
Questions about compounded medication are welcome at your consultation. If you'd like to talk about brand-name options, raise it with your clinician.
Semaglutide or tirzepatide: what's the difference?
Both are prescription medicines that work on the body's appetite signals. They aren't interchangeable, and which one suits you, if either, depends on your history, your other medicines and how you respond.
One hormone pathway
- What it is
- A GLP-1 receptor agonist. It acts like GLP-1, a gut hormone released after you eat.
- How it works
- It helps you feel full sooner and for longer, slows how fast your stomach empties and quiets appetite signals in the brain.
- Brand names you may know
- Ozempic and Wegovy are brand-name semaglutide, made by Novo Nordisk.
Two hormone pathways
- What it is
- A dual GIP and GLP-1 receptor agonist. It acts on two gut hormone pathways instead of one.
- How it works
- Like semaglutide, it works on fullness, stomach emptying and appetite, through both the GLP-1 and GIP pathways.
- Brand names you may know
- Mounjaro and Zepbound are brand-name tirzepatide, made by Eli Lilly.
Searching for Ozempic, Wegovy, Mounjaro or Zepbound in Naples? What we prescribe is compounded semaglutide or tirzepatide, prepared by a licensed Florida compounding pharmacy. It isn't the brand-name product, and it isn't FDA-approved. Your clinician explains the difference at your consultation.
How it's given
Semaglutide and tirzepatide are usually given as a small injection under the skin, most often once a week. Doses usually start low and are raised gradually, which helps with side effects. Your clinician shows you how your own prescription is given before you take it home.
Common side effects
Nausea, diarrhea, vomiting, constipation and stomach discomfort are the most common, and they're often most noticeable when you start or when the dose goes up. Severe or lasting stomach pain needs medical attention straight away. We go through all of this before you start.
Keeping your muscle
When appetite drops, it's easy to eat too little protein. Your plan covers eating enough protein and staying active, including strength work, so you keep as much muscle as you can.
Who GLP-1 medication is for, and who should wait.
A GLP-1 prescription is a medical decision, not a purchase. These are the questions your clinician works through with you before anything's prescribed.
Who it's usually considered for
The brand-name versions are approved for adults with obesity, and for adults who are overweight with a weight-related health problem such as high blood pressure, type 2 diabetes or high cholesterol. Your clinician looks at your weight history, your health and what you've already tried.
Who shouldn't take it
- Anyone with a personal or family history of medullary thyroid cancer, or of MEN 2
- Anyone pregnant, trying to get pregnant or breastfeeding
- Anyone with a history of pancreatitis, gallbladder or kidney problems, or diabetic eye disease, until it's been discussed in full
Other causes worth checking
Thyroid problems, hormone changes, poor sleep and some medicines can all make weight harder to shift. Your clinician may suggest a wellness lab panel so your plan starts from the full picture.
Storing it in the Naples heat
Store your medication exactly as the pharmacy label says, and never leave it in a parked car. In a Florida summer, a parked car gets far hotter than these medicines can tolerate.


Built around your week.
Medication is one tool. Your plan also looks at how you eat, move and sleep, around the life you actually have.
An assessment, not a sales appointment
If medication isn't right for you, we'll say so, and talk through the other routes with you.
Supervised, not handed off
Weight loss medication isn't a prescription you collect and forget. We follow up, adjust and manage side effects with you.
No surprises, start to finish.
Nothing's booked on the day unless you want it to be.
- 1
Your free consultation
We review your history, your goals and any medications you're already taking, then talk through which options are appropriate for you, including the possibility that medication isn't the right route.
- 2
Starting treatment
If you and your clinician decide to go ahead, your program is prescribed and supervised by our clinical team. You'll know the price before you commit.
- 3
Ongoing supervision
We follow up, adjust your plan and manage side effects with you, for as long as you're on the program.
The people you'll actually see.
Every visit is with a member of our medical team. Not a rotating roster, not a chart number.
Medical direction by Victor Cruz, MD, our Medical Director. Our weight loss programs are physician-supervised.
Meet the whole team- Alexandra Moon, APRNAdvanced Practice Registered Nurse

- Robert Hall, APRNAdvanced Practice Registered Nurse

Our Naples care teamThe faces who'll welcome you and look after you on 1st Ave N.
Weight loss clinic in Naples, FL
Our weight loss clinic in Naples, FL is part of a practitioner-led medical spa at 848 1st Ave N. Every program is physician-supervised by our medical director, and it starts with a free consultation, not a prescription.
Weight loss programs in Naples, FL
Weight loss programs in Naples, FL here are built around your history, your goals and your week. Medication is one option, alongside how you eat, move and sleep, and your clinician tells you if it isn't the right route for you.
A GLP-1 program near you in Naples
If you're looking for a GLP-1 program near you in Naples, we're downtown on 1st Ave N, open 7 days a week, 8am to 8pm. Your clinician reviews your history first, and medication is prescribed only when it's appropriate.
Comparing weight loss centers in Naples, FL
Comparing weight loss centers in Naples, FL? Ask each one who supervises the program, whether your history comes before a prescription, what's in the medication and how follow-ups work. We'll answer all four at your free consultation.
How much does medical weight loss cost in Naples?
It depends on the program you and your clinician agree on, so we don't list prices here. The consultation is free, and you get a price before you commit to anything.
Are your GLP-1 medications FDA-approved?
The semaglutide and tirzepatide we prescribe are compounded by a licensed Florida compounding pharmacy. Compounded medications aren't FDA-approved. Brand-name versions are FDA-approved for specific uses. Your clinician tells you exactly what you'd be prescribed, and why, before you start.
Do I have to take medication?
No. The consultation is an assessment, not a sales appointment. If medication isn't appropriate for you, we'll say so.
Who supervises my program?
Our weight loss programs are physician-supervised by Victor Cruz, MD, our Medical Director. Every visit is with a member of our clinical team.
Are there side effects?
All of these medications have possible side effects, and your clinician goes through them with you in full before you start. That conversation is part of the consultation, and we manage side effects with you once you've started.
How long does it take to see results?
That varies by person and by program. Your clinician will set realistic expectations with you rather than promise a number.
Is compounded semaglutide the same as Ozempic or Wegovy?
No. Ozempic and Wegovy are brand-name semaglutide, FDA-approved for specific uses. Compounded semaglutide contains the same active ingredient but is prepared for an individual prescription by a licensed compounding pharmacy, and it isn't FDA-approved. Your clinician explains exactly what you'd be prescribed.
What's the difference between semaglutide and tirzepatide?
Semaglutide acts on one gut hormone pathway, GLP-1. Tirzepatide acts on two, GLP-1 and GIP. Both work on fullness and appetite. Which suits you, if either, depends on your history, your other medicines and how you respond, and it's decided with your clinician.
How is semaglutide or tirzepatide given?
Usually as a small injection under the skin, most often once a week, starting at a low dose that's raised gradually. Your clinician shows you how your own prescription is given before you take it home.
Who shouldn't take semaglutide or tirzepatide?
Anyone with a personal or family history of medullary thyroid cancer or MEN 2, and anyone pregnant, trying to get pregnant or breastfeeding. A history of pancreatitis, gallbladder or kidney problems, or diabetic eye disease needs a full discussion first.
Do I still need to change how I eat?
Yes. Medication is one tool. Your plan covers eating enough protein, staying active and sleeping well, so the changes hold up and you keep as much muscle as you can.
Are you open on weekends?
Yes. We're open 7 days a week, 8am to 8pm, at 848 1st Ave N in downtown Naples. Consultations are bookable online or by phone from 9am to 5pm every day.
Start here
Start with a free consultation.
No pressure and no commitment. We talk through what you'd like to change, what's realistic and what it costs. You decide from there.
THE PATIENT AND ANY OTHER PERSON RESPONSIBLE FOR PAYMENT HAS A RIGHT TO REFUSE TO PAY, CANCEL PAYMENT, OR BE REIMBURSED FOR PAYMENT FOR ANY OTHER SERVICE, EXAMINATION, OR TREATMENT THAT IS PERFORMED AS A RESULT OF AND WITHIN 72 HOURS OF RESPONDING TO THE ADVERTISEMENT FOR THE FREE, DISCOUNTED FEE, OR REDUCED FEE SERVICE, EXAMINATION, OR TREATMENT.
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